*http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct0920bhansali

Citation: Bhansali, A.; Asokumra,P.; Walia, R.; Bhansali, S.; Gupta, V.; Jain, A.; Sachdeva, N.; Sharma, R. R.; Marwaha, N.; Khandelwal, N. Efficacy and Safety of Autologous Bone Marrow Derived Stem Cell Transplantation in patients with Type 2 Diabetes mellitus: A randomized placebo-controlled study. Cell Transplantation.

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Cell Transplantation Center of Excellence for Agin. “Transplant With Own Bone Marrow Stem Cells Reduces Insulin Use In Type 2 Diabetes Patients.” Medical News Today. MediLexicon, Intl., 2 Jul. 2013. Web.
2 Jul. 2013. <http://www.medicalnewstoday.com/releases/262696.php>

“There is growing interest in the scientific community for cellular therapies that use bone marrow-derived cells for the treatment of type 2 diabetes mellitus and its complications,” said study corresponding author Anil Bhansali, PhD professor and head of the Endocrinology Department at the Post Graduate Institute of Medical Education in Chandrigarh, India. “But the potential of stem cell therapy for this disease is yet to be fully explored.”

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Appeared or available online: April 2, 2013

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While there is growing interest in using stem cell transplantation to treat TD2M, few studies have examined the utility of bone marrow-derived stem cells. By experimenting with bone marrow-derived stem cells, the researchers sought to exploit the rich source of stem cells in bone marrow.

The researchers recommended determining which type of stem cells -hematopoietic, bone marrow or placenta-derived – might be best to treat T2DM. In addition, they said that post-transplantation patients needed close monitoring for the development of neoplasia as stem cells – whether multipotent or pluripotent – have the potential for malignant transformation.

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APA

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Cell transplantation had a significant impact on the patients in this study as those administered cells demonstrated a significant reduction in insulin requirement. A significantly smaller reduction in the insulin requirement of the control group was also observed but a “repeated emphasis on life style modification” was believed to be a contributing factor in this effect.