Main Category: Neurology / Neuroscience
Also Included In: Stem Cell Research
Article Date: 02 Jul 2013 – 1:00 PDT
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A team of researchers in Poland who treated three of six paraplegics with spinal cord injury using transplanted olfactory ensheathing cells found that the three treated patients showed neurological improvement and no adverse effects while the three control patients who did not receive transplants saw no improvement.
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The researchers added that the modest improvements in neurological function occurred against a “background of intense neuro-rehabilitation, which is probably needed for the improvements, although the experience of the control patients indicated that this in itself is not sufficient.” neurology / neuroscience section for the latest news on this subject.
* http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct0799tabakow
Citation: Tabakow, P.; Jarmundowicz, W.; Czapiga, B.; Fortuna, W.; Miedzybrodzki, R.; Czyz, M.; Huber, J.; Szarek, D.; Okurowski, S.; Szewczyk, P.; Gorski, A.; Raisman, G. Transplantation of autologous olfactory ensheathing cells in complete human spinal cord injury. Cell Transplantation.
“Neurophysiological examinations showed improvement in spinal cord transmission and activity of lower extremity muscles in the surgically treated patients, but not in patients receiving only neuro-rehabilitation,” they said.
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Patients With Spinal Cord Injury Treated With Own Olfactory Ensheathing Cells Realize Neurologic Improvement
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“We consider that the transplantation of OECs was the main factor contributing to the neurologic improvements in the three transplanted patients,” said Dr. Tabakow. “Among the possible mechanisms for improvement is that the transplanted OECs may have mediated some restitution along white matter tracts in these patients.”
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MLA
According to the researchers, among the various kinds of neurotrophic cells being tested for transplantation to treat spinal cord injury, OECs deserve “special attention” because they are unique in their natural ability to stimulate regrowth of lesioned axons and “evoke long-distance axon regeneration and subsequent recovery of locomotion in paralyzed limbs.”
Cell Transplantation Center of Excellence for Aging and Brain Repair
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Appeared or available online: April 2, 2013
In a phase one of this non-randomized controlled study, the team of researchers treated the three patients with transplanted self-donated (autologous) OECs and fibroblasts isolated from olfactory mucosa combined with “intense” neuro-rehabilitation. They found the treatment “safe and feasible” one year after transplantation. There was no evidence of neurological deterioration, neuropathic pain, neuroinfection or tumor growth, wrote the researchers.
APA
Cell Transplantation Center of Excellence for Agin. (2013, July 2). “Patients With Spinal Cord Injury Treated With Own Olfactory Ensheathing Cells Realize Neurologic Improvement.” Medical News Today. Retrieved from
http://www.medicalnewstoday.com/releases/262698.php.
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