Novel treatment for stroke and possibly other neurological diseases

Aug 29th, 2013 · Comments Off

Main Category: Stroke
Also Included In: Stem Cell Research
Article Date: 29 Aug 2013 – 0:00 PDT

The rats’ physical agility and neurological responses were tested before stroke and after treatment with the exosomes, and the results were compared.


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Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats


Journal of Cerebral Blood Flow & Metabolism advance online publication 21 August 2013; doi: 10.1038/jcbfm.2013.152

The researchers induced stroke by occluding an artery in the brain of each rat to block blood flow for two hours. Twenty-four hours later, they injected the exosomes into a vein in each rat’s tail.

“All rats showed severe functional loss one day after treatment, but gradual and eventually significant improvement during the four-week period that followed,” Dr. Chopp says. “This discovery provides a novel treatment for stroke, and possibly other neurological diseases.”

In the latest in a series of experiments testing the use of stem cells to treat neurological disease, researchers at Henry Ford Hospital have shown for the first time that microscopic material in the cells offers a “robust” treatment for crippling stroke.

Henry Ford Health System. “Novel treatment for stroke and possibly other neurological diseases.” Medical News Today. MediLexicon, Intl., 29 Aug. 2013. Web.
29 Aug. 2013. <http://www.medicalnewstoday.com/releases/265291.php>

The research team found that after inducing stroke in lab rats, injecting exosomes containing this genetic material into their blood prompted remodeling of the affected brain, including increased production of new brain cells, blood vessels and neural rewiring. Together, these effects significantly improved neurological function that had been impaired by stroke.

Dr. Chopp and Henry Ford researchers earlier found that the beneficial effects of treatment of stroke with bone marrow cells are attributed to their production and release of exosomes. In addition, using a similar treatment with exosomes from bone marrow stem cells significantly reduced a particularly resistant form of malignant brain tumor in living lab rats.

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It focused on exosomes, blister-like microscopic “bubbles” that once were thought to carry and get rid of “old” proteins that were no longer needed by the body. After they were recently found to also carry RNA, whole new fields of study were suggested – including the pioneering work at Henry Ford.

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Funding source: NIH grants R01AG037506 (MC), R01 NS066041 (YL), and R01NS081189 (HX)

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“In this study we pioneered a totally new treatment for stroke, and possibly for all neurological disease,” says Michael Chopp, Ph.D., scientific director of the Henry Ford Neuroscience Institute.


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Using bone marrow from the adult rats, the researchers extracted stem cells – specifically mesenchymal cells, or MSCs – that were then employed to generate exosomes.

The new study is published online in the current issue of Journal of Cerebral Blood Flow and Metabolism.

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