MRI spectroscopy is highly sensitive for lipid-soluble metabolites from UC-MSCs

Main Category: Stem Cell Research
Also Included In: MRI / PET / Ultrasound;  Neurology / Neuroscience
Article Date: 11 Sep 2013 – 1:00 PDT

The researchers confirm that soluble metabolite spectrum has an important role to reflect lipid metabolic changes in the cytoplasm and cell membrane, a comprehensive analysis of spectral characteristics of water- and lipid-soluble metabolite extracts from mesenchymal stem cells provides a more comprehensive understanding of their metabolic characteristics, in order to achieve the best detection efficiency under the condition of reducing cell usage.

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Research, Neural Regeneration. “MRI spectroscopy is highly sensitive for lipid-soluble metabolites from UC-MSCs.” Medical News Today. MediLexicon, Intl., 11 Sep. 2013. Web.
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Haiyang Dai and colleagues from Shantou University Medical College used methanol-chloroform and perchloric acid to extract lipid-soluble metabolites and water-soluble metabolites, respectively. Furthermore, a dual phase extraction method using methanol-chloroform and water was used to obtain both water and lipid fractions simultaneously.

The following image shows a typical 1H-nuclear magnetic resonance spectrum of the lipid-soluble metabolites of human umbilical cord mesenchymal stem cells. The concentration of glutamate extracted with the dual phase extraction method (lower) was higher than that obtained with the methanol-chloroform method (upper):

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MRI spectroscopy is highly sensitive for lipid-soluble metabolites from UC-MSCs

1H-nuclear magnetic resonance spectrum

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Among the different extraction procedures, perchloric acid was more efficient in extracting water-soluble metabolites and methanol-chloroform was efficient in extracting organic components compared with the dual phase extraction method. Nuclear magnetic resonance spectroscopy was found to be highly sensitive for analyzing lipid-soluble extracts.

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FA: Fatty acids; TMS: tetramethylsilane; DPE: dual phase extraction.
Credit: Neural Regeneration Research


These findings were published in the Neural Regeneration Research (Vol. 8, No. 22, 2013).

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Dai HY, Hong BK, Xu ZF, Ma L, Chen YW, Xiao YY, Wu RH. Nuclear magnetic resonance spectroscopy is highly sensitive for lipid-soluble metabolites. Neural Regen Res. 2013;8(22):2103-2110.

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The water-soluble metabolite profile of human mesenchymal stem cells is known, but the lipid profile remains unclear.

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