Making tumor-targeting T cells in a dish
Aug 13th, 2013 · Comments Off
Main Category: Stem Cell Research
Also Included In: Cancer / Oncology
Article Date: 13 Aug 2013 – 2:00 PDT
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Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy
Nature. “Making tumor-targeting T cells in a dish.” Medical News Today. MediLexicon, Intl., 13 Aug. 2013. Web.
13 Aug. 2013. <http://www.medicalnewstoday.com/releases/264706.php>
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Making tumor-targeting T cells in a dish
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A method for producing from stem cells a large quantity of human immune cells capable of killing tumor cells in mice is presented in a paper published online this week in Nature Biotechnology. The approach may make it easier to implement cancer ‘immunotherapies’ – a suite of treatments that activate the immune system to attack tumors.
Nature Biotechnology (2013) doi:10.1038/nbt.2678
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Most cancer immunotherapy strategies require isolation of immune cells called T cells from the blood of cancer patients. However, T cells that specifically recognize and kill only tumor cells but not healthy cells are very rare, and the problem is how to generate large numbers of such cells. Previous work has shown that either T cells can be engineered to express tumor-specific receptors or they can be grown in large numbers using ‘reprogramming’ technology.
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