Main Category: Cancer / Oncology
Also Included In: Ear, Nose and Throat; Stem Cell Research
Article Date: 21 Jun 2013 – 0:00 PDT
Specifically, the study shows that an enzyme called “protein kinase C-epsilon” (PKCepsilon) adds energy-packing phosphate groups to the Nanog molecule. This phosphorylation of Nanog stabilizes and activates the molecule.
Patient / Public: | ![]() |
It also triggers a series of events: Two Nanog molecules bind together, and these are joined by a third “co-activating” molecule called p300. This molecular complex then binds to the promoter region of a gene called Bmi1, an event that increases the expression of the gene. This, in turn, stimulates proliferation of cancer stem cells. |
Healthcare Prof: | ![]() |
5 (1 votes) |
A new study led by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) has identified a biochemical pathway in cancer stem cells that is essential for promoting head and neck cancer.
Current ratings for:
Growth Of Head And Neck Cancer Promoted By The Nanog Protein
Please note: If no author information is provided, the source is cited instead.
Contact Our News Editors
Normally, Nanog helps healthy embryonic stem cells maintain their undifferentiated, uncommitted (i.e., pluripotent) state. But recent evidence suggests that Nanog promotes tumor growth by stimulating the proliferation of cancer stem cells.
MLA
Ohio State University Medical Center
“Our work shows that the PKCepsilon/Nanog/Bmi1 signaling axis is essential to promote head and neck cancer,” Pan says. “And it provides initial evidence that the development of inhibitors that block critical points in this axis might yield a potent collection of targeted anti-cancer therapeutics that could be valuable for the treatment of head and neck cancer.” cancer / oncology section for the latest news on this subject.