Main Category: Stem Cell Research
Also Included In: Vascular
Article Date: 16 Oct 2013 – 1:00 PDT
“Evaluating the gene and protein signatures of stem cells from each patient may allow for a more individualized approach, so that every patient receives mesenchymal stem cells that are most likely to promote blood vessel growth and cardiac repair. Hopefully, this will substantially increase the efficacy of stem cell treatments for heart patients.”
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They analyzed the genetic signature and proteins of the respective cell lines and found that the vessel-supporting stem cell line released high levels of a blood vessel guidance molecule – SLIT3. In the mixture that didn’t form blood vessels, the SLIT3 gene was hardly expressed, Rehman said.
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Building human blood vessels in engineered tissues
“Some stem cells actually have multiple jobs,” says Dr. Jalees Rehman, associate professor of cardiology and pharmacology at the UIC College of Medicine and lead author of the paper. For example, stem cells in the bone marrow, he said, differentiate into bone or cartilage, but also have a secondary role in helping to support other cells in the bone marrow.
Their findings, which could help improve the vascularization of engineered tissues, were reported online in the Journal of Molecular and Cellular Cardiology.
The researchers demonstrated that when they mixed mesenchymal stem cells from human bone marrow with the endothelial cells that line blood vessels, the stem cells elongated to form scaffolds and the endothelial cells organized around them to form tubes.
University of Illinois at Chicago. “Building human blood vessels in engineered tissues.” Medical News Today. MediLexicon, Intl., 16 Oct. 2013. Web.
16 Oct. 2013. <http://www.medicalnewstoday.com/releases/267466.php>
Rehman and his colleagues, who are developing engineered tissues for use in cardiac patients, observed that certain stem cells in bone marrow, called mesenchymal stem cells, seemed crucial for organizing other cells into functional blood vessels.
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“But without the stem cells, the endothelial cells just sat there,” said Rehman.
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